FUNDING-EPA
-- MICROELECTRONIC MONITORING OF CELLULAR STATUS (PRESOL); March 22,
2018
Agency
Environmental
Protection Agency (EPA)
Description
The
Environmental Protection Agency requires a contractor to perform
microelectronic monitoring of cells in culture to measure altered cellular
physiology/pathology in response to exposure to potential environmental
toxicants. Use of this approach provides a sensitive measure of changes in
cellular physiology that may correlate with toxic activities of test compounds.
These results will be used in the ToxCast Project
for prioritizing compounds for more in-depth toxicological evaluation. Use of
physiologically relevant cells (lines) is required, including cells with phase I
and phase II metabolic capabilities as well as primary cells. Co-cultures of
multiple cell types that provide relevant physiological conditions are also of
interest. The Contractor shall use a microelectronic cell monitoring system to
measure the response of one or more rodent or human cells types to compounds
from the ToxCast library. The compounds from the
ToxCast library will be supplied to the contractor
by the EPA or by an EPA contractor.
Announcement
Number:
18-233-SOL-00115
Closing
Date:
Mar
22, 2018 3:00 pm Eastern
Link
to Full Announcement
https://www.fbo.gov/?s=opportunity&mode=form&id=3ecc29ac8e4a94ad0671b91215a9cb41&tab=core&_cview=0
Contact
Information
POC
Jimmy Nguyen