(FOA)-Advancing
Toxicokinetics For
Efficient And Robust Chemical Evaluations (EPA-G2019-STAR-D1); September 10,
2019
Agency
US
Environmental Protection Agency (EPA)
Description
The
U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve
Results (STAR) program, is seeking applications proposing to advance the
development of chemical toxicokinetic tools and
approaches for broader applicability during chemical evaluations, with an
emphasis on their application within new approach methodology (NAM) frameworks.
Toxicokinetics describes the absorption,
distribution, metabolism, and excretion of chemicals and their metabolites by
the body, and as such provides a framework for extrapolating in vivo
doses of concern from in vitro-derived concentrations that cause
perturbations at the cellular or molecular level. The incorporation of new
methods, tools and approaches can simultaneously improve predictivity, reduce uncertainty and build confidence in
the successful application of such extrapolations. Institutional
cost-sharing is not required.
Announcement
Number:
EPA-G2019-STAR-D1
Closing
Date:
September
10, 2019
Link
to Full Announcement
https://www.grants.gov/web/grants/view-opportunity.html?oppId=318797
Contact
Information
Barbara
Klieforth
202-564-7223