Funding-Radiochemistry
and Radionuclide Imaging Instrumentation; April 19,
2010
Agency
Chicago
Service Center
Description
The
Office of Biological and Environmental Research (BER) of the Office of Science (SC),
U.S. Department of Energy (DOE) advances world-class biological and
environmental research programs and scientific facilities for DOE missions in
energy, environment, and basic research. The Radiochemistry and Radionuclide
Imaging Instrumentation Research program within BER,
supports fundamental research for developing new methodologies for real-time,
high-resolution imaging of dynamic biological processes in living systems. This
research has two integrated goals: First, the research supports the DOE Science
mission-related activities in bioenergy and
bioremediation; Second, the fundamental methodologies
developed under DOE-funded research may serve as tools leading to
transformational new technologies for use in nuclear medicine research and
applications supported by NIH and industry. Applicants are encouraged to meet
these two goals. Responses to this Fu nding
Opportunity Announcement (FOA) should address the development and use of highly
innovative radiotracer chemistry or instrumentation technologies for
quantitative in vivo measurement of site-specific chemical reactions, their
spatial distributions and metabolic perturbations, and ensuing biological
processes with a high degree of accuracy and sensitivity. BER hereby announces
its interest in receiving applications for research grants in two topic areas,
Radiochemistry and Radionuclide Imaging Instrumentation. In the area of
Radiochemistry, BER invites applications for fundamental research to improve
synthetic methodology for rapidly and efficiently incorporating radionuclides into a wide range of organic molecules.
Approaches should use methods that allow dual or multiple labeling of targeting
molecules for dual energy or hybrid imaging techniques in intact living systems
and/or in vivo models. Development of microfluidics
for synthesis and purification are also appropr iate. In the area of Radionuclide Imaging Instrumentation,
BER invites applications to design and develop new or improved radionuclide
detection and imaging instrumentation. These improvements should significantly
increase the accuracy of quantitative assessments of the three dimensional
spatial and temporal distribution of radiotracers in living systems, allow the
screening of large numbers of intact living systems (e.g. plants), or the
screening of cells to identify desirable characteristics. Development of
instruments which allow simultaneous examination of biological systems using
different modalities to improve understanding is also encouraged. Applications
should focus on basic research that will significantly advance the current
state of the science underpinning biological systems of importance to the
mission of the DOE, and which may also have application in nuclear medicine.
Announcement
Number: DE-FOA-0000265
Closing
Date: Apr 19, 2010
Link
to Full Announcement
https://www.fedconnect.net/FedConnect/
Contact
Information
Kimberlie J. Laing, Grant Analyst, 301-903-3026
kim.laing@science.doe.gov
Prem C. Srivastava,
Technical-Scientific Program Contact, 301-903-4071
prem.srivastava@science.doe.gov
kim.laing@science.doe.gov