Funding-Environmental Influences
during Windows of Susceptibility in Breast Cancer Risk (U01); November 30, 2009
Key Dates
Letters of Intent Receipt Date: November 30, 2009
Application Receipt Date: December 30, 2009
Executive Summary
Purpose. This Funding Opportunity Announcement (FOA) issued by the
National Institute of Environmental Health Sciences (NIEHS) and the National
Cancer Institute (NCI) solicits cooperative agreement grant applications from
institutions to conduct basic laboratory or ancillary research projects
involving existing populations or clinical studies focused on gene-environment
interactions, as well as the molecular mechanisms engaged, during specific
windows of susceptibility that have the potential of modifying a woman’s
lifetime risk for developing breast cancer. These activities run in parallel
with a limited competition FOA to support ongoing epidemiological
investigations as well as a FOA to assume Coordinating Functions for the Breast
Cancer and Environment Research Program (BCERP; see RFA-ES-09-008
and RFA-ES-09-010,
respectively). The BCERP supports transdisciplinary
research on the interactions of environmental factors (including chemical,
physical, and social environmental) with genetic factors during windows of
susceptibility throughout a woman’s lifespan that potentially influence breast
cancer risk. Each research project is required to partner with a local
community-based or advocate organization focused on breast cancer as a
concern. Community partners will assist with outreach activities to
include, but not limited to, translating and communicating research finding to
the public and policy makers as well as building and promoting partnerships
among researchers, community members, and other engaged stakeholders. The
community partners are expected to participate collaboratively with all the
members of the BCERP Network, but especially with existing Community Outreach
and Translation Cores associated with the ongoing epidemiologic investigations
in supporting communication, outreach, and translation of research findings
from the BCERP.
- Mechanism of
Support. This
FOA will utilize the NIH cooperative agreement (U01) grant mechanism and
runs in parallel with two additional FOAs (RFA-ES-09-008
and RFA-ES-09-010)
that will collectively constitute the Breast Cancer and Environment
Research Program (BCERP) network.
- Funds Available
and Anticipated Number of Awards. The total amount of funding NIEHS
and NCI expect to award through this mechanism is $2.7 million per year
for five years. It is anticipated that up to 6 awards will be made through
this announcement.
- Budget and
Project Period.
The total project period for an application submitted in response to this
funding opportunity may not exceed five years. Direct costs are limited to
$300,000 per year for a five-year period.
- Application
Research Plan Component Length. The research plan, including specific
aims, background, preliminary studies and research design and methods
sections, should be no more than 25 pages.
- Eligible
Institutions/Organizations. Institutions/organizations listed in Section
III, 1.A. are eligible to apply.
- Eligible Project
Directors/Principal Investigators (PDs/PIs). Individuals
with the skills, knowledge, and resources necessary to carry out the
proposed research are invited to work with their institution/organization
to develop an application for support. Individuals from underrepresented
racial and ethnic groups as well as individuals with disabilities are
always encouraged to apply for NIH support. PDs/PIs for the BCERP Windows
of Susceptibility study (this FOA) or Limited Competition Epidemiologic
study (see RFA-ES-09-008)
must not be the same PDs/PIs for the Coordinating Center (see RFA-ES-09-010)
but may be members of the same institutions.
- Number of
PDs/PIs.
More than one PD/PI (i.e., multiple PDs/PIs), may be designated on the
application.
- Number of
Applications.
Applicants may submit more than one application, provided they are
scientifically distinct.
- Resubmissions.
Resubmission
applications are not permitted in response to this FOA.
- Renewals. Renewal
applications are not permitted in response to this FOA.
- Special Date(s).
This
FOA uses non-standard due dates. See Receipt,
Review and Anticipated Start Dates
- Application
Materials. See
Section
IV.1 for application materials.
- Hearing
Impaired.
Telecommunications for the hearing impaired are available at: TTY: (301)
451-5936
For Further
Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-09-009.html