Funding-NIH AND CDC
SMALL BUSINESS INNOVATION RESEARCH (SBIR) CONTRACT PROPOSALS; November 9, 2009
Agency
Department
of Health and Human Services
Description
This
notice is not a duplication of PHS-2010-1, originally posted August 4, 2009. The
response date should have been November 9, 2009.
National Institutes of Health, Bethesda, MD 20892 and Centers for Disease
Control and Prevention, Atlanta, GA 30305 are soliciting proposals from small
business concerns that possess the research and development (R&D) expertise
to conduct innovative research that will contribute toward meeting the program
objectives of the agencies. A SOLICITATION OF THE NATIONAL INSTITUTES OF HEALTH
(NIH) AND THE CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) FOR SMALL
BUSINESS INNOVATION RESEARCH CONTRACT PROPOSALS [PHS 2010-1], with a closing
date of November 9, 2009, for receipt of proposals, soon will be available
electronically through the NIH Small Business Research Funding Opportunities (http://grants.nih.gov/grants/funding/sbir.htm)
Web site. The SBIR Phase I Contract Solicitation will be available ONLY via
electronic means. Printed copies of the Solicitation will not be distributed.
Potential offerors are encouraged to check the NIH
Small Business Research Funding Opportunities Web site for updates on the
program. Any updates or corrections to the Solicitation will be posted there.
The purposes of the SBIR program are to: (a) stimulate technological innovation;
(b) use small business to meet Federal Research/Research & Development
(R/R&D) needs; (c) foster and encourage participation by socially and
economically disadvantaged small business concerns and by small business
concerns that are 51 percent owned and controlled by women, in technological
innovation; and (d) increase private sector commercialization of innovations
derived from Federal R/R&D, thereby increasing competition, productivity
and economic growth. For purposes of the SBIR program, a small business concern
is any business concern that, on the date of award, (1) is organized for
profit, with a place of business located in the United States, which operates
primarily within the United States or which makes a significant contribution to
the United States economy through payment of taxes or use of American products,
materials or labor; (2) is in the legal form of an individual proprietorship,
partnership, limited liability company, corporation, joint venture,
association, trust or cooperative, except that where the form is a joint
venture, there can be no more than 49 percent participation by foreign business
entities in the joint venture; (3) is at least 51 percent owned and controlled
by one or more individuals who are citizens of, or permanent resident aliens
in, the United States; or is owned and controlled by another (one) small
business concern that is itself at least 51 percent owned and controlled by one
or more individuals who are citizens of, or permanent resident aliens in, the
United States; AND (4) has, including its affiliates, no more than 500
employees. Following are the research topics identified in the NIH/CDC SBIR
Contract Solicitation [PHS 2010-1]: NATIONAL INSTITUTES OF HEALTH (NIH)
--NATIONAL CANCER INSTITUTE (NCI): Biopsy Instruments and Devices that Preserve
Molecular Profiles in Tumors; Development of Molecular Pharmacodynamic
Assays for Targeted Therapies; Point of Care Analysis of Circulating Tumor
Cells for Cancer Diagnostics, Prognosis and Treatment; Development of Anticancer
Agents; Process Analytic Technologies (PAT) for Biologics: Innovative Methods
for Monitoring and Analyzing Product Quality and Safety During Manufacture of
Cancer Therapeutics; Innovative Devices to Protect Radiosensitive Organs and
Structures During Radiation Therapy; Quantitative Cell-Based Imaging For
Clinical Diagnosis and Treatment; Development of Generic Antibodies for the
Treatment of Cancer; Development of Novel Medicinal Food Products for the
Mitigation of the Side-Effects of Cancer Chemotherapy; Companion Diagnostics:
Predictive and Prognostic Tests Enabling Personalized Medicine in Cancer
Therapy; Data Harmonization and Advanced Computation of Population Health Data;
Facilitating the Transfer of Statistical Methodology into Practice; Direct
Sequencing of Nucleic Acids Without Clonal
Amplification or Synthesis for the Molecular Characterization of Cancer;
Biosensors for Early Cancer Detection and Risk Assessment; Imaging of Cancer
Stem Cells; Development of a Molecular Diagnostic Assay to Detect Basal-like
Breast Cancer; Alternative Biospecimen Stabilization
and Storage Solutions; Multifunctional Therapeutics and Theranostics
Based on Nanotechnology; Nanotechnology Imaging Agents or Devices for Improved
Detection of Cancer; Nanotechnology Sensing Platforms for Improved Cancer
Detection; Development of Alternative Affinity Capture Reagents for Cancer
Proteomics Research; Physical Property-Based High-Throughput Protein
Sequencing; siRNA Resource for Synthetic Lethal
Screening of DNA Repair and Damage Signaling Networks. NATIONAL CENTER FOR
RESEARCH RESOURCES (NCRR): Visualizing Biomedical Research Characteristics;
Collecting, Integrating, Accessing and Using Disease Models-Related Data.
NATIONAL HEART, LUNG AND BLOOD INSTITUTE (NHLBI): Technologies for In Vivo
Electrophysiology Studies in Transgenic and Knock Out Mice and Other Small
Animals; Protein Capture Agents for Cardiovascular Research; Innovative Tools,
Techniques, and Software for the Screening, Recruitment, and Follow-up of
Participants in Pediatric Research; Interventional MRI and X-ray Invasive Hemodynamics Telemetry; Catheter for Delivering High
Intensity Focused Ultrasound for Transluminal and Endocavitary Interventional MRI; Development of Blood Donor
Screening Tests for the Presence of Human Babesia
Microorganisms. NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA):
Identification of miRNAs as Biomarkers for
Alcohol-Induced Disorders; Real-time Detection of Neurochemical
Changes in Response to Alcohol Drinking; Biomarkers for Alcohol-Induced
Disorders; Human Stem Cells as a Model for Understanding and Treatment of
Alcohol Induced Tissue Damage; Alcohol Biosensors and Data Analysis Systems;
Generation of Rat Knockout Strains for Alcohol Research. NATIONAL INSTITUTE Of
ALLERGY AND INFECTIOUS DISEASES (NIAID): Aminoglycosides:
Formulation for Oral Delivery; High Throughput in Vitro Immunization System For
Evaluating Human B Cell Immune Responses to HIV-1 Vaccine Antigens; In Vitro
Immunization System For Evaluating Human T Cell Immune Responses to HIV-1
Vaccine Antigens. NATIONAL INSTITUTE ON DRUG ABUSE (NIDA): New Technologies:
Integrating Data from Prescription Monitoring Program(s) to Current Clinical
Practice; Development of Innovative Techniques/Tools for the Screening, Recruitment,
and Follow-up of Clinical Trial Participants ; Innovative Diagnostic Drug
Screening Tests for Drug of Abuse; Marketing Evidence-Based Prevention
Interventions for Substance Abuse Prevention; Using Handheld Devices to Support
Recovery; Tools to Promote Security and Appropriate Prescribing of Scheduled
Prescription Drugs; Innovative Technologies to Support Economic Research in the
Drug Abuse Treatment System; Development of State-of-the-Art Mechanisms for
Epidemiological Research; Rapid and Sensitive Method for Nicotine and Its
Metabolites in Biological Fluids; Tool Development for New or Improved Capture
Reagents; Development of Alternate Drug Delivery Dosage Forms for Drugs Abuse
Studies; Design and Synthesis of Treatment Agents for Drug Abuse; Pharmaceutical
Approaches for Development of Pharmacotherapies for
Drug Addiction; Web Based Cognitive/Neuropsychological Testing for Substance
Abuse. NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS): Computer
Assisted Sperm Analysis System; Development of Quantitative High Throughput
Screens For Environmental Toxicants that Induce DNA Damage; Development of Mid
to High-Throughput Toxicological Tests Using Model Organisms; Integrated
Prediction Systems to Support Environmental Toxicological Assessments;
Incorporation of Metabolism into Quantitative High Throughput Screening( HTS)
Assays; Development of Quantitative High Throughput Screens for the Detection
of Chemicals That Modulate Gap Junctional
Intercellular Communication; Monitoring in vivo Gene Expression Changes After
Exposure to Toxicants in Caenorhabditis Elegans; Development of Biomarkers for Assessment of
Exposure to Molds. CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) – NATIONAL
CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION (NCCDPHP):
Development of a Method to Detect Traces of Natural Rubber and Silicone in
Biological Specimens. NATIONAL CENTER FOR HIV/AIDS, VIRAL HEPATITIS, STD, AND
TB PREVENTION (NCHHSTP): Manufacture of a Novel Technology to Identify Early
HCV Infection by anti-HCV Detection; An Integrated Relational Database Storage
and Data Mining Software for Large-Scale Analyses of Infections Caused by
Hepatitis Viruses; Decision Support Tools and the Electronic Health Record
(EHR). NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES (NCIRD): Novel
Methods for Detecting Viruses in Clinical Samples; Novel or Enhanced Technology
for Vaccination Delivery and Immunization Programs. NATIONAL CENTER FOR
ZOONOTIC, VECTOR-BORNE & ENTERIC DISEASES (NCZVED): Development of Soaps or
Lotions Containing Natural Product Repellents or Toxicants for Tick and
Mosquito Disease Vectors; Novel Methods for Detecting Parasites in Clinical
Samples. COORDINATING OFFICE FOR TERRORISM PREPAREDNESS AND EMERGENCY RESPONSE
(COTPER): Computer-Based Models For Evaluating Strategies and Outcomes in
Pandemic Preparedness; Development of an Improved Reusable Insulated
[Cold-Chain] Shipping Container (ISC); Training in Public Health Ethics for
Public Health Responders ; State, Local, Community and Faith Based Tools and
Resources for Protecting Vulnerable Populations from Excess Health Burden
During All-Hazards Events; Pre-Hospital Transport Vehicle for the Acutely
Injured; Technologies for Rapid and Efficient Communication in Emergency
Response
2. NIH/CDC SBIR Contract Solicitation PHS 2010, including proposal forms, will
be available electronically on/around August 19, 2009 through the NIH Small
Business Research Funding Opportunities Web site. (Note: The PHS 2009-2 Omnibus
Solicitation of the National Institutes of Health, Centers for Disease Control
and Prevention, and Food and Drug Administration for Small Business Innovation
Research (SBIR) and Small Business Technology Transfer (STTR) GRANT
Applications, where investigator-initiated ideas are encouraged, is still open
and is available at the same Web site noted above with remaining due dates of
August 5 and December 5, 2009.) To understand better the differences between
grants and contracts, see Contracts vs. Grants: What's the difference? (http://grants.nih.gov/grants/funding/contracts_vs_grants.htm)
LINKURL: http://grants.nih.gov/grants/funding/sbir.htm
LINKDESC: National Institutes of Health Small Business (SBIR/STTR) Research
Funding Opportunities. E-mail: sbir@od.nih.gov
Announcement
Number: PHS-2010-1A
Closing
Date: Nov 09, 2009 5:00 pm
Link
to Full Announcement
Contact
Information
Office
of Extramural Programs, Office of Extramural Research,
National
Institutes of Health
Phone:
301-435-2688