Funding-Limited Submission – Genomics of Transplantation Cooperative Research Program; September 21, 2010

 

Purpose. The National Institute of Allergy and Infectious Diseases (NIAID) invites new or renewal applications from single institutions or consortia of institutions to participate in a cooperative interdisciplinary research program for large-scale, broad-scope genomic studies in clinical transplantation of solid organ, tissue, and cells. The goals of this program are to identify and characterize gene polymorphisms and gene expression patterns that: (1) correlate with and/or predict transplantation outcomes; (2) define immune responses relating to the onset and severity of acute and chronic graft rejection; (3) predict responses to immunosuppression to allow tailoring of therapy; and (4) elucidate the genetic basis of variability in graft survival between populations or individuals. The long-term goal of the program is to understand the genetic basis of immune-mediated graft rejection and differences in transplant outcomes to provide a rational basis for developing more effective treatments to improve long-term graft survival and provide a better quality-of-life for transplant patients.

 

Mechanism of Support. This Funding Opportunity Announcement (FOA) will utilize the single project (U01) and multi-project (U19) Cooperative Agreement award mechanism.

 

Funds Available and Anticipated Number of Awards. The NIAID anticipates that approximately $4 million total costs will be available in FY 2011 to fund two to four new or renewal U01 and/or U19 awards.

 

Number of Applications. An institution may not submit more than two applications. An individual PD/PI may only submit one application as PD/PI or as part of a multiple PD/PI team. However, a PD/PI may serve as a collaborator on another U01/U19 application provided there is no scientific overlap with the application submitted as the PD/PI or as part of a multiple PD/PI team.

 

Additional information and guidelines: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-10-019.html

 

Because NIAID limits an institution to two applications, the University of Kentucky has established an internal selection process. Individuals interested in submitting to this program are to send the following information electronically to the Office of the Vice President for Research at vpr@email.uky.edu and a copy to their Associate Dean for Research by Tuesday, September 21, 2010:

·         Names and departments of Project Director and other key personnel

·         Specify if application is for a single project (U01) or multi-projects (U19)

·         Overview (1-2 pages total) – include descriptive title of proposed research project(s), specific aims, long range objectives and proposed activities

 

A committee will be appointed to review the information and make recommendations as to the University’s submissions. Deadlines are October 19, 2010 (optional letter of intent) and November 19, 2010 (complete application).

 

Questions about the submission process may be sent to Ms. Annette Evans in the Office of the Vice President for Research (alevan4@email.uky.edu or 257-1663.)