Funding-Molecular
Targets for Cancer Prevention with Nutritional Combinations, June 30, 2010
Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm
Executive Summary
- Purpose. This Funding
Opportunity Announcement (FOA), issued by the National Cancer Institute
(NCI), and the Office of Dietary Supplements (ODS), of the National
Institutes of Health (NIH), invites research applications to enhance our
understanding about the dynamic interrelationship that exists between
bioactive food components (and/or combinations thereof) and cancer
prevention. Although much evidence exists that
dietary components are linked to cancer prevention, the interactions among
dietary bioactive compounds and food combinations remains
under-investigated. Applications are encouraged to consider either
multiple dietary bioactive components, intact foods or multiple foods
utilizing physiologically relevant concentrations of the agents. New
genetic technologies may be employed to study the impact of dietary
components on complex cellular and molecular networks, as part of the
effort to better understand the basis for the multifaceted interactions of
food components with cancer prevention mechanisms. Specifically,
applications that apply new high-throughput genomic, epigenomic,
proteomic, and metabolomic technologies to
prioritize molecular targets of dietary components are highly encouraged.
The sites of action that may be evaluated include carcinogen metabolism,
DNA repair, cell proliferation, apoptosis, differentiation, hormonal
regulation, energetics, inflammation, and/or
angiogenesis. In addition, applications should either evaluate multiple
molecular targets within a cancer process or multiple processes in order
to prioritize which process(es)
is/are most involved in bringing about a phenotypic change. It is hoped
that advances in this area may assist in optimizing cancer prevention
while minimizing potential toxicity due to food components. The resulting
information will help define which foods or food components should be
considered in isolation or in combination when developing dietary
strategies to reduce cancer risk and/or modify tumor behavior.
- Mechanism of
Support. This
FOA will utilize the NIH Research Project Grant (R01) award mechanism.
- Funds Available
and Anticipated Number of Awards. Awards issued under this FOA are contingent
upon the availability of funds and the submission of a sufficient number
of meritorious applications.
- Budget and
Project Period.
Because the nature and scope of the proposed research will vary from
application to application, it is anticipated that the size and duration
of each award will also vary. The total amount awarded and the number of
awards will depend upon the mechanism numbers, quality, duration, and
costs of the applications received.
- Application
Research Strategy Length: The R01 application Research
Strategy section of the PHS398 may not exceed 12 pages, including
tables, graphs, figures, diagrams, and charts. See Table
of Page Limits.
- Eligible
Institutions/Organizations. Institutions/organizations listed in Section
III, 1.A. are eligible to apply.
- Eligible Project
Directors/Principal Investigators (PDs/PIs). Individuals
with the skills, knowledge, and resources necessary to carry out the
proposed research are invited to work with their institution/organization
to develop an application for support. Individuals from underrepresented
racial and ethnic groups as well as individuals with disabilities are
always encouraged to apply for NIH support.
- Number of
PDs/PIs.
More than one PD/PI (i.e., multiple PDs/PIs), may be designated on the
application.
- Number of
Applications. Applicants
may submit more than one application, provided that each application is
scientifically distinct.
- Resubmissions. Applicants may
submit a resubmission application, but such application must include an
Introduction addressing the previous peer review critique (Summary
Statement). See new NIH policy on resubmission (amended) applications (NOT-OD-09-003,
NOT-OD-09-016).
- Renewals. Applications
can be renewed by competing for additional project periods
- Application
Materials.
See Section
IV.1 for application materials. All applications,
including resubmission, revision and renewal, submitted for due dates
January 25, 2010 and beyond, must utilize the current forms and
instructions.
- General
Information.
For general information on SF424 (R&R) Application and Electronic
Submission, see these Web sites:
- Hearing
Impaired. Telecommunications
for the hearing impaired are available at: TTY: (301) 451-5936
For Further
Information: http://grants.nih.gov/grants/guide/pa-files/PA-10-035.html