(FOA)-New
Bioimaging Approaches for Bioenergy; April 4,
2019
Agency
Department
of Energy
Office
of Science
Description
The
DOE SC Biological Systems Science Division (BSSD) in Biological and
Environmental Research (BER) hereby announces its interest in receiving
applications to support fundamental research towards enabling new bioimaging
approaches to achieve an advanced understanding of plant and microbial systems
relevant to bioenergy research. New quantum dot (QD)-based-imaging approaches
including quantum probes and sensors, and complementary optical imaging
instrumentation, are needed to allow the observation and characterization of
multiple complex biological processes occurring within living plant and
microbial systems, including rhizosphere and soil microbiomes. Processes of
interest include, but are not limited to measuring enzyme function within cells,
tracking metabolic pathways in vivo, monitoring the transport of materials
within cells or across cellular membranes, monitoring signaling processes
between cells within plant-microbe and microbe-microbe interactions. Development
of probes and sensors with desirable optical properties functionalized with
specific biologically active molecules to interact and bind with specific
cellular targets of interest are encouraged. Proposed approaches should enable
dynamic localization and imaging to facilitate testing and validation of
hypothesized cellular processes. It is expected that applications will make use
of quantum-dot enabled approaches for imaging of biological targets
non-destructively and in real time, to dramatically enhance our ability to
measure biological processes in and among living cells.
Announcement
Number
DE-FOA-0002041
Pre-application
Due Date
April
4, 2019
Application
Due Date
May
20, 2019
Link
to Full Announcement
https://www.grants.gov/web/grants/view-opportunity.html?oppId=311953
Contact
Information
Prem
Srivastava
prem.srivastava@science.doe.gov
(301) 903-4071