(FOA)-Large Animal Testing Centers for Evaluation of Somatic Cell Genome Editing Tools (U42 - Clinical Trial Not Allowed) (RFA-RM-18-014); August 24, 2018

 

Agency National Institutes of Health

 

Description

The purpose of this Funding Opportunity Announcement (FOA) is to support Large Animal Testing Centers to evaluate in vivo genome editing technologies developed by other investigators in the Somatic Cell Genome Editing Program (SCGE). Each Testing Center will use wild-type pigs or non-human primates, as well as reporter animals developed under RFA-RM-18-013. The Testing Centers will work collaboratively with investigators funded under RFA-RM-18-016 and RFA-RM-18-017 to assess efficacy and safety of in vivo genome editing and delivery technologies. Testing Centers will breed, archive and maintain cohorts of well characterized and genotyped large animals, establish methods and protocols for the evaluation of the delivery systems and editing tools, conduct testing and provide results to the SCGE Dissemination and Coordination Center. Such activities will accelerate the translation of genome editing technologies into treatments for human diseases. 

 

Activity Code:

 

U42 Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements

 

Announcement Number:

 

RFA-RM-18-014

 

Closing Date:

 

August 24, 2018

 

Link to Full Announcement

 

https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-18-014.html