(FOA)-Multi-Site
Study of the Health Implications of Exposure to PFAS-Contaminated Drinking
Water; May 30, 2019
Agency
Department
of Health and Human Services
Centers for Disease Control and
Prevention
Description
The
Agency for Toxic Substances and Disease Registry (ATSDR) is soliciting research
to commence a multi-site study on the human health effects of exposures to
drinking water contaminated with per- and polyfluoroalkyl substances (PFAS). Proposed study sites
must include communities using PFAS-contaminated private residential wells or
public water systems. Exposure assessment will be based on measured PFAS serum
levels as well as estimated PFAS serum levels derived from pharmacokinetic
modeling of reconstructed PFAS drinking water concentrations over time.
Specifically, grant awardees will be required to conduct historical
reconstruction/water modeling in order to determine the PFAS concentration.
Effect biomarkers such as lipids and tests of immune and thyroid function
derived from pharmacokinetic modeling of reconstructed PFAS drinking water
concentrations over time will be evaluated. ATSDR intends this research to be a
two-part program consisting of (1) a mandatory core research protocol to allow
ATSDR to aggregate the core data and to compare laboratory and statistical
analyses across sites, and (2) each successful awardee will have the option to
propose additional investigator-initiated research questions and hypotheses
related to the overall goals of this NOFO. Successful awardees will be expected
to send all serum and urine samples to an ATSDR facility or an ATSDR-designated
facility for analysis. ATSDR will provide recipients with details regarding
sample transfer within the first 6 months post award. All data resulting from
the sample analysis will be stored by ATSDR. ATSDR will share each site's sample
testing results with them in addition to additional de-identified data for all
sites.
Eligibility: Applicant
institutions submitting applications with essentially the same proposed research
to two or more CDC NOFOs will not be funded under more than one
NOFO.
Announcement
Number
RFA-TS-19-002
Closing
Date
May
30, 2019
Link
to Full Announcement
https://www.grants.gov/web/grants/view-opportunity.html?oppId=314434
Contact
Information
Dan
Holcomb