Funding-DHHS metals in medicine grants; deadlines vary, post until August 30, 2009

Department of Health and Human Services

Participating Organizations
National Institutes of Health (NIH), (http://www.nih.gov)

Components of Participating Organizations
National Institute of General Medical Sciences (NIGMS), (http://www.nigms.nih.gov)
National Cancer Institute (NCI), (http://www.nci.nih.gov)
National Institute of Environmental Health Sciences (NIEHS), (http://www.niehs.nih.gov)
Office of Dietary Supplements (ODS), (http://dietary-supplements.info.nih.gov/)

Title:  Metals in Medicine (R01)

Announcement Type
This Funding Opportunity Announcement (FOA) is a reissue of PA-07-276.

Program Announcement (PA) Number: PA-08-251

NOTICE: Applications submitted in response to this Funding Opportunity Announcement (FOA) for Federal assistance must be submitted electronically through Grants.gov (http://www.grants.gov) using the SF424 Research and Related (R&R) forms and the SF424 (R&R) Application Guide. 

APPLICATIONS MAY NOT BE SUBMITTED IN PAPER FORMAT.

This FOA must be read in conjunction with the application guidelines included with this announcement in Grants.gov/Apply for Grants (hereafter called Grants.gov/Apply).

A registration process is necessary before submission and applicants are highly encouraged to start the process at least four (4) weeks prior to the grant submission date. See Section IV.

For Assistance downloading this or any Grants.gov application package, please contact Grants.gov Customer Support at http://grants.gov/CustomerSupport

Catalog of Federal Domestic Assistance Number(s)
93.859, 93.393, 93.113

Key Dates
Release/Posted Date: August 25, 2008
Opening Date: September  5, 2008 (Earliest date an application may be submitted to Grants.gov) 
Letters of Intent Receipt Date(s): Not Applicable
NOTE: On-time submission requires that applications be successfully submitted to Grants.gov no later than 5:00 p.m. local time (of the applicant institution/organization). 
Application Due Date(s):  Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm
AIDS Application Due Date(s):  Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#AIDS.
Peer Review Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
Council Review Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
Earliest Anticipated Start Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
Additional Information To Be Available Date (URL Activation Date): Not Applicable
Expiration Date: September  8, 2011

Due Dates for E.O. 12372
Not Applicable

Additional Overview Content

Executive Summary

• Purpose.   The objective of this Funding Opportunity Announcement (FOA), issued by the National Institute of General Medical Sciences (NIGMS), National Cancer Institute (NCI), National Institute of Environmental Health Sciences (NIEHS), and the Office of Dietary Supplements (ODS), National Institutes of Health is to encourage research that bridges the areas of inorganic chemistry and medicine.  The mechanisms by which organisms control transition metal ions and the roles of these metals in cellular regulation and signaling in health and disease are of principal interest.  The interactions of synthetic inorganic complexes with living systems and their components are an additional area of interest.  These areas are linked by the need to involve researchers having a deep understanding of inorganic chemistry in medically relevant research.  Much of the work is expected to involve collaborations including chemists, biologists, and medical researchers.  The results will be relevant to understanding the mechanisms of metal handling by biological systems and the basic cellular roles underlying the nutritional requirement for essential metals.  It is expected that this research will also contribute to the identification of new targets for drug discovery, diagnostics, and future therapeutic approaches involving metal complexes, although drug development, per se, is not a focus of the program.
• Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) grant mechanism.
• Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.
• Budget and Project Period.  The total project period for an application submitted in response to this funding opportunity may not exceed 5 years.  The requested budget for an R01 award is not limited in dollars but needs to reflect the actual needs of the proposed project.
• Application Research Plan Component Length: The R01 application Research Plan component of the PHS398 (Items 2-5) may not exceed 25 pages, including tables, graphs, figures, diagrams, and charts. http://grants.nih.gov/grants/funding/funding_program.htm
• Eligible Institutions/Organizations. Institutions/organizations listed in Section III, 1.A. are eligible to apply.
• Eligible Project Directors/Principal Investigators (PDs/PIs). Include Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
• Number of PDs/PIs. More than one PD/PI (i.e., multiple PDs/PIs), may be designated on the application.
• Number of Applications. Applicants may submit more than one application, provided that each application is scientifically distinct.
• Resubmissions.  Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement).
• Renewals.   Applicants may submit a renewal application..
• Application Materials. See Section IV.1 for application materials.
• General Information. For general information on SF424 (R&R) Application and Electronic Submission, see these Web sites:

· SF424 (R&R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm

· General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/

• Hearing Impaired. Telecommunications for the hearing impaired are available at: TTY 301-451-0088. 

Link to Full Announcement:  http://grants.nih.gov/grants/guide/pa-files/PA-08-251.html